How does persimmon leaf flavonoid promote brain ischemic tolerance?

December 2nd, 2013

This shows the effects of 200 mg/kg persimmon leaf flavonoid on intercellular adhesion molecule-1 expression in the hippocampus after cerebral ischemia/reperfusion (immunohistochemical staining, × 400). Credit: Neural Regeneration Research

Studies have found that brain ischemic tolerance is associated with endothelial cells, inflammatory factor and intercellular adhesion molecule, but its mechanism of action role in prevention and treatment of cerebral ischemia is still not very clear. Prof. Mingsan Miao and team from Henan University of Traditional Chinese Medicine found that persimmon leaf flavonoid mitigates pathological injury of brain tissue following cerebral ischemia/reperfusion in brain ischemic tolerance rats and elevates brain ischemic tolerance, and high-dose persimmon leaf flavonoid showed an identical effect to ginaton.

These findings, published in the Neural Regeneration Research (Vol. 8, No. 28, 2013), provide the basis for the utilization and development of persimmon leaves and for drug development in the prevention and treatment of cerebral ischemia.

More information:
Miao MS, Zhang XX, Bai M, Wang LN. Persimmon leaf flavonoid promotes brain ischemic tolerance. Neural Regen Res. 2013;8(28):2625-2632

Provided by Neural Regeneration Research