Tumor microenvironment analyzed to increase effectiveness of preclinical trials

Senior Lecturer Valeriya Solovyova's project received Russian President's support.

She will be allocated 600 thousand rubles in funding for her inquiries into oncosuppressors and apoptosis activation.

"Currently, it's very important to find new ways of cancer therapy that could be effective, targeted and not very toxic. Traditional chemotherapy is marked by low specificity, which leads to heavy side effects like damage to normal cells of the spinal cord, lymph, epithelium, or hair follicles. That's why we work on new methods based on gene and cell technologies that can be both effective and safe," says the winner.

Dr. Solovyova adds that oncosuppressors and apoptosis activators selectively destroy cancer cells, and immunomodulators stimulate the organism to fight the tumor. In her latest study, it was shown that co-culturing HeLa adenocarcinoma cells, peripheral blood mononuclear cells, and mesenchymal stromal cells results in changes in the proliferative activity of the peripheral blood mononuclear cells and mesenchymal stromal cell populations.

More information:
Analysis of the Interaction and Proliferative Activity of Adenocarcinoma, Peripheral Blood Mononuclear and Mesenchymal Stromal Cells after Co-Cultivation In Vitro

doi.org/10.1007/s12668-019-00625-z

Kristina V. Kitaeva, Tikhon S. Prudnikov, Marina O. Gomzikova, Sevindzh K. Kletukhina, Victoria James, Albert A. Rizvanov, Valeriya V. Solovyeva

Provided by Kazan Federal University