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JNK3 expression after traumatic brain injury

July 15th, 2013
JNK3 expression after traumatic brain injury
Cell apoptosis is shown in the peripheral area of the cerebral cortex of rats at six hours after in traumatic brain injury (TUNEL staining). The arrow shows brown positive apoptotic cells with thickening nuclei. Credit: Neural Regeneration Research

Increasing evidence has revealed that the activation of the JNK pathway participates in apoptosis of nerve cells and neurological function recovery after traumatic brain injury. However, which genes in the JNK family are activated and their role in traumatic brain injury remain unclear. Dr. Jiang Long and colleagues from the First Affiliated Hospital of Kunming Medical University, China found that JNK3 expression was downregulated at early stages of brain injury, which may be associated with apoptosis of nerve cells. Downregulation of JNK3 expression may promote the recovery of neurological function following traumatic brain injury. These findings were published in the Neural Regeneration Research (Vol. 8, No. 16, 2013).

More information:
Long J, Cai L, Li JT, Zhang L, Yang HY, Wang TH. JNK3 involvement in nerve cell apoptosis and neurofunction recovery after traumatic brain injury. Neural Regen Res. 2013;8(16):1491-1499. www.sjzsyj.org:8080/Jweb_sjzs/ … ttachType=PDF&id=642

Provided by Neural Regeneration Research

Citation: JNK3 expression after traumatic brain injury (2013, July 15) retrieved 30 July 2026 from https://sciencex.com/wire-news/135342652/jnk3-expression-after-traumatic-brain-injury.html
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