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The mechanism of astragaloside IV promoting sciatic nerve regeneration

September 11th, 2013
The mechanism of astragaloside IV promoting sciatic nerve regeneration
This sky blue staining is seen in the high-density myelin sheath in the moderate-dose astragaloside IV group (5 mg/kg per day). Credit: Neural Regeneration Research

Astragaloside IV, the main component of the traditional Chinese medicine astragalus membra-naceus, has been shown to inhibit inflammation, oxidation, and apoptosis, and exerts immu-noregulatory effects. Xiaohong Zhang and colleagues from School of Pharmacutical Sciences, Jilin University investigated whether astragaloside IV could promote the repair of injured sciatic nerve. Denervated sciatic nerve of mice was subjected to anastomosis.

The mice were intraperitoneally injected with 10, 5, 2.5 mg/kg astragaloside IV per day for 8 consecutive days. The researchers found that astragaloside IV contributed to sciatic nerve regeneration and functional recovery in mice. The mechanism underlying this effect may be associated with the upregulation of growth-associated protein-43 expression.

These findings were published the Neural Regeneration Research (Vol. 8, No. 24, 2013).

More information:
Zhang XH, Chen JJ. The mechanism of astragaloside IV promoting sciatic nerve regeneration. Neural Regen Res. 2013;8(24):2256-2265.

Provided by Neural Regeneration Research

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