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S14G-humanin is a new hope for Alzheimer's disease

October 30th, 2013
S14G-humanin is a new hope for Alzheimer's disease
Fibrillar amyloid-beta 40 (3) generated reactive oxygen species in hippocampal neurons, and humanins (6) could block the effect of fibrillar amyloid-beta 40 on reactive oxygen species at 12 days after treatment. Credit: Neural Regeneration Research
Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults. Al-though effective, the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear.

A recent study by Xue Li and colleagues from Henan Provincial People's Hospital, China investigated the inhibitory effects of S14G-humanin on amyloid-beta protein-induced hippocampal neuronal injury, and data from this study showed that fibrillar amyloid-beta 40 disturbed cellular homeostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen species, and decreasing the mitochondrial membrane potential. S14G-humanin blocked the effects of amyloid-beta 40 on the neuronal cell membrane, and restored the disturbed cellular homeostasis, thereby exhibiting a potential and effective treatment for Alzheimer's disease.

These findings were published in the Neural Regeneration Research (Vol. 8, No. 27, 2013).

More information:
S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein, Li X, Zhao WC, Yang HQ, Zhang JH, Ma JJ. S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein. Neural Regen Res. 2013;8(27):2573-2580.

Provided by Neural Regeneration Research

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