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Active component from wine-processed Fructus corni inhibits hippocampal neuron apoptosis

November 27th, 2013
Active component from wine-processed Fructus corni inhibits hippocampal neuron apoptosis
After pretreatment with 5-hydroxymethylfurfural, some mitochondria were swollen, but morphology was mostly normal in H2O2-injured rat hippocampal neurons (transmission electron microscope, × 4 000). Credit: Neural Regeneration Research

Studies have shown that Fructus corni has a protective effect on hepatocytes, and has anticancer, antioxidative, anti-inflammatory and antiseptic properties. 5-hydroxymethylfurfural, a compound extracted from wine-processed Fructus corni, has a protective effect on hippocampal neurons damaged by H2O2. Prof. Mingyan Wang and team from Nanjing University of Chinese Medicine for the first time, used cytobiological and molecular biology methods to investigate the molecular mechanisms underlying the neuroprotective effects of 5-hydroxymethylfurfural on rat hippocampal neurons injured by oxidative stress.

Researchers found that 5-hydroxymethylfurfural could protect against H2O2-induced rat hippocampal neuron apoptosis by regulation of expression levels of the apoptosis-related genes p53, bcl-2, bax and caspases. This finding, published in the Neural Regeneration Research (Vol. 8, No. 28, 2013), provides theoretical evidence for the treatment of neurodegenerative disease with 5-hydroxymethylfurfural extracted from wine-processed Fructus corni and lays the foundations for clinical prevention and treatment of oxidative injury-related diseases in the brain.

More information:
Gu H, Jiang ZQ, Wang MY, Jiang HY, Zhao FM, Ding X, Cai BC, Zhan Z. 5-Hydroxymethylfurfural from wine-processed Fructus corni inhibits hippocampal neuron apoptosis. Neural Regen Res. 2013;8(28):2605-2614.

Provided by Neural Regeneration Research

Citation: Active component from wine-processed Fructus corni inhibits hippocampal neuron apoptosis (2013, November 27) retrieved 27 July 2026 from https://sciencex.com/wire-news/147005774/active-component-from-wine-processed-fructus-corni-inhibits-hipp.html
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