This Science News Wire page contains a press release issued by an organization and is provided to you "as is" with little or no review from Science X staff.

Kaixin Jieyu Fang for treatment of vascular depression

March 27th, 2014
Kaixin Jieyu Fang for treatment of vascular depression
After 21 days of Kaixin Jieyu Fang administration, transmission electron microscopy revealed that myelin sheath thickening and delamination was obviously reduced, leading to an increased number of myelin sheaths. Credit: Neural Regeneration Research

The Chinese compound Kaixin Jieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. Dr. Ying Zhang and co-workers from Guang'anmen Hospital, China Academy of Chinese Medical Sciences in China This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries.

Rats received daily intragastric administration of a suspension of Kaixin Jieyu Fang powder. Kaixin Jieyu Fang was made from two prescriptions of Kaixin San and Sini San supplemented with Radix Morindae Offcinalis, consisting of eight Chinese herbs including Radix Ginseng, Radix Bupleuri, Fructus Aurantii Immaturus, Radix Morindae Officinalis, Poria, Radix Polygalae, Radix Paeoniae Rubra and Radix Glycytthizae. After treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased.

These results, published in the Neural Regeneration Research (Vol. 9, No. 1, 2014), indicate that Kaixin Jieyu Fang can alleviate cerebral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression.

More information:
Zhang Y, Huang SJ, Wang YY, Pan JH, Zheng J, Zhang XH, Chen YX, Li DJ. Mechanism underlying the protective effect of Kaixin Jieyu Fang on vascular depression following cerebral white matter damage. Neural Regen Res. 2014;9(1):61-68.

Provided by Neural Regeneration Research

Citation: Kaixin Jieyu Fang for treatment of vascular depression (2014, March 27) retrieved 25 July 2026 from https://sciencex.com/wire-news/157372725/kaixin-jieyu-fang-for-treatment-of-vascular-depression.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Back to list