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Molecular regulation of hypoxic-ischemic brain damage

May 12th, 2014

Oligodendrocyte lineage gene 1 (Olig1) plays a key role in hypoxic-ischemic brain damage and myelin repair. miRNA-9 is involved in the occurrence of many related neurological disorders. Bioinformatics analysis demonstrated that miRNA-9 complementarily, but incompletely, bound oligodendrocyte lineage gene 1, but whether miRNA-9 regulates oligodendrocyte lineage gene 1 remains poorly understood.

Dr. Lijun Yang and co-workers from Beijing Friendship Hospital, Capital Medical University in China prepared whole brain slices from a rat model of oxygen-glucose deprivation and explored dynamic expression pattern of Olig1 during hypoxic-ischemic brain damage and after miRNA-9 transfection. Results from their study showed that miRNA-9 possibly negatively regulated oligodendrocyte lineage gene 1 in brain tissues during hypoxic-ischemic brain damage.

The relevant study has been reported in the Neural Regeneration Research (Vol. 9, No. 5, 2014).

More information:
Yang LJ, Cui H, Cao T. Negative regulation of miRNA-9 on oligodendrocyte lineage gene 1 during hypoxic-ischemic brain damage. Neural Regen Res. 2014;9(5):513-518.

Provided by Neural Regeneration Research

Citation: Molecular regulation of hypoxic-ischemic brain damage (2014, May 12) retrieved 7 April 2026 from https://sciencex.com/wire-news/161347863/molecular-regulation-of-hypoxic-ischemic-brain-damage.html

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