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Acrylamide exposure impairs blood-cerebrospinal fluid barrier function

May 19th, 2014

The blood-brain barrier prevents xenobiotics from entering the central nervous system.

Growing evidence indicates that neurotoxins, such as tributyltin, manganese and nanoparticles, may disrupt the function of the blood-brain and blood-cerebrospinal fluid (CSF) barriers. Previous studies show that chronic acrylamide exposure leads to central and peripheral neuropathy. However, very few studies have focused on the effects of acrylamide exposure on these barriers. Prof. Yanshu Zhang and co-workers from Hebei United University in China found that acrylamide exposure damages the blood-cerebrospinal fluid barrier and impairs secretory and transport functions. These changes may underlie acrylamide-induced neurotoxicity.

The research achievements have been published in the Neural Regeneration Research (Vol. 9, No. 5, 2014).

More information:
Yao X, Yan LC, Yao L, Guan WJ, Zeng FX, Cao FY, Zhang YS. Acrylamide exposure impairs blood-cerebrospinal fluid barrier function. Neural Regen Res. 2014;9(5):555-560

Provided by Neural Regeneration Research

Citation: Acrylamide exposure impairs blood-cerebrospinal fluid barrier function (2014, May 19) retrieved 25 July 2026 from https://sciencex.com/wire-news/161948521/acrylamide-exposure-impairs-blood-cerebrospinal-fluid-barrier-fu.html

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