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Signaling pathway for ginsenoside Rb1 promoting hippocampal neuronal neurite outgrowth

July 15th, 2014
Signaling pathway for ginsenoside Rb1 promoting hippocampal neuronal neurite outgrowth
After hippocampal neurons were treated with amyloid-beta (23-25) for 2 days, viable cells exhibited regular and round nuclei with pallid blue fluorescence, whereas apoptotic cells (arrows) were characterized by condensation and fragmentation of nuclei. Credit: Neural Regeneration Research

The main pathological changes of Alzheimer's disease (AD) include amyloid-beta protein-induced hippocampal neuronal injury and neurite outgrowth impairment. Phosphatidylinositol 3-kinase (PI3K)/Akt pathway and mitogen-activated protein kinase (MAPK) pathway are the important signaling pathways respectively responsible for regulating synaptic plasticity and neuronal survival.

In view of the fact that ginsenoside Rb1 exhibits anti-aging and anti-dementia effects, Prof. Qionglan Yuan and her team, Department of Anatomy & Neurobiology, Tongji University School of Medicine, Shanghai, China performed a study, in which ginsenoside Rb1 was used, and found that ginsenoside Rb1 promoted hippocampal neuronal neurite outgrowth and protected against neurotoxicity induced by amlyloid-beta (23-25) via a mechanism involving Akt and extracellular signal-regulated kinase 1/2 signaling.

Related results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014).

More information:
Liu J, He J, Huang L, Dou L, Wu S, Yuan QL. Neuroprotective effects of ginsenoside Rb1 on hippocampal neuronal injury and neurite outgrowth. Neural Regen Res. 2014;9(9):943-950.

Provided by Neural Regeneration Research

Citation: Signaling pathway for ginsenoside Rb1 promoting hippocampal neuronal neurite outgrowth (2014, July 15) retrieved 24 July 2026 from https://sciencex.com/wire-news/166882682/signaling-pathway-for-ginsenoside-rb1-promoting-hippocampal-neur.html
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