Vilcek Prize lecture
Alexander J. Varshavsky, Ph.D.
Howard & Gwen Laurie Smits Professor of Cell Biology
California Institute of Technology
Pasadena, California
Recent Discoveries About the Ubiquitin
System and the N-End Rule Pathway
Over the last two decades, it became clear that control of cellular functions through ubiquitin
conjugation and regulated protein degradation rivals, and often surpasses in significance,
classical regulation through transcription and translation. I shall describe recent discoveries in
the laboratory that greatly expanded the functional scope of the N-end rule pathway, a distinct
subset of the ubiquitin system.
Thursday, April 8, 2010
4:00 p.m.
New York University School of Medicine
Smilow 1st Floor Seminar Room
Smilow Research Center
Provided by Vilcek Foundation