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Vilcek Prize lecture

April 8th, 2010

Alexander J. Varshavsky, Ph.D.

Howard & Gwen Laurie Smits Professor of Cell Biology

California Institute of Technology

Pasadena, California

Recent Discoveries About the Ubiquitin

System and the N-End Rule Pathway

Over the last two decades, it became clear that control of cellular functions through ubiquitin
conjugation and regulated protein degradation rivals, and often surpasses in significance,
classical regulation through transcription and translation. I shall describe recent discoveries in
the laboratory that greatly expanded the functional scope of the N-end rule pathway, a distinct
subset of the ubiquitin system.

Thursday, April 8, 2010

4:00 p.m.

New York University School of Medicine

Smilow 1st Floor Seminar Room

Smilow Research Center

Provided by Vilcek Foundation

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