Successful Phase III clinical trial results reported for Novocure's novel medical device for treatment of recurrent glio

Data from the first phase III clinical trial of NovoCure's NovoTTF
device for treatment of patients with recurrent glioblastoma (GBM) were presented today as a
late breaking abstract during the Neuro-Oncology session at the American Society of Clinical
Oncology (ASCO) Annual Meeting in Chicago. Study results show that NovoTTF, a novel, noninvasive,
portable medical device, may be as or more effective than the best available
chemotherapies for GBM, but without the toxicity usually associated with cytotoxic or targeted
treatments.

The study enrolled 237 patients with recurrent, late-stage GBM, the most malignant form of
primary brain cancer. Using low intensity, alternating electric fields to disrupt tumor growth,
NovoTTF is the first non-drug, non-radiation, non-surgical treatment approach to show promise
of clinical benefit for the treatment of brain cancer.

"We are continuously researching treatments that offer patients with recurrent glioblastoma a
better quality of life while not compromising potential efficacy or patient safety," said Philip
Gutin, M.D., primary investigator for the study; chair of the Department of Neurosurgery, coexecutive
director of the Brain Tumor Center, and Fred Lebow chair in Neuro-Oncology of
Memorial Sloan-Kettering Cancer Center. "Data from this non-invasive, non-chemotherapy
option are encouraging, and could establish this device as another treatment option for this
population."

The randomized, controlled, phase III clinical trial compared NovoTTF monotherapy with the
best available chemotherapy, as determined by the study physicians in the US and Europe, in
patients with recurrent, late-stage GBM. In the intent-to-treat population, patients treated with
NovoTTF lived as long as those treated with the best available chemotherapy, including
bevacizumab (median overall survival 6.6 months vs. 6.0 months; p=ns). Overall response rate
(complete and partial responses according to investigator assessment using Macdonald
Criteria) was higher for NovoTTF compared with chemotherapy (11.7% vs. 5.9%).

In a per-protocol population, which included approximately 80% of patients in the trial, who
completed at least one course of treatment — either NovoTTF treatment or the best available
chemotherapy — NovoTTF patients experienced an increase in median overall survival
compared with the best available chemotherapy (7.8 months vs. 6.1 months; 28% increase;
p<0.05). in this group, overall response rate (complete and partial responses according to
investigator assessment using macdonald criteria) was much higher in the novottf group than
in the best available chemotherapy group (15.1% vs. 5.1%).

In addition, NovoTTF treatment was associated with 3-4 times fewer infections, and less
hematological and gastrointestinal side effects compared to standard chemotherapy. In the
NovoTTF-treated group, mild-to-moderate skin irritation (mainly rash) beneath the device
electrodes was the most frequent treatment-related adverse event (less than 20% of patients).
Skin irritation was generally resolved using topical corticosteroids and by periodic relocation of
the device electrodes.

"In the study, NovoTTF proved to be a valid treatment option for cancer patients. The study
showed that NovoTTF was well tolerated by GBM patients and should be considered a
reasonable treatment option for recurrent GBM," said Roger Stupp, M.D., of the Department of
Neurosurgery of the University of Lausanne Medical Center (CHUV), Switzerland. Dr. Stupp is a
world renowned leader in glioblastoma research and father of the standard of care "Stupp
protocol" using combined radiotherapy and temozolomide in newly diagnosed GBM patients.

"We're pleased to present the first phase III data for this novel treatment modality, which holds
promise for people with recurrent GBM," said Asaf Danziger, chief executive officer of
NovoCure. "The NovoTTF is approved for sale in Europe. NovoCure is planning to submit a
premarket approval application (PMA) to FDA in the near future. We look forward to our
interactions with the U.S. Food and Drug Administration on the PMA and we are hopeful that
NovoTTF will be made available in the future to U.S. patients."

An ongoing US and European, multi center, phase III study of NovoTTF combined with
chemotherapy for the treatment of newly diagnosed GBM was initiated in 2009.

The NovoTTF is an investigational device in the United States and has not been approved by
FDA for sale in the US for any use. NovoCure currently has CE Mark for NovoTTF and the
treatment is available to patients in Europe.

Provided by Edelman Public Relations