The EU CAR-T Handbook released to advance clinical practice and education

The EBMT, the EHA, and the GoCART Coalition have released the second edition of the "EU CAR-T Handbook," a comprehensive, open-access resource covering the latest developments in CAR-T cell therapies. This updated edition provides expanded insights into scientific advances, clinical applications, and evolving regulatory frameworks.

Developed with contributions from leading experts in academia and industry, the new edition includes approximately 50% more chapters than the first and offers broader coverage of clinical management, including emerging indications such as autoimmune diseases. It also introduces content on other immune cellular therapies such as tumor-infiltrating lymphocytes, extending the handbook's relevance to solid tumors.

Given the rapid evolution of the field—marked by new products, indications, and advances in related therapies such as bispecific antibodies—this edition reflects significant shifts in clinical decision-making and redefines treatment algorithms. It incorporates international perspectives, further enhancing its value as a global reference for health care professionals.

Professor Christian Chabannon, Editor-in-Chief, stated, "The EU CAR-T Handbook is a key component of our educational efforts and will serve as the foundational material for the upcoming CAR-T Passport—a practical resource for clinicians, nurses, pharmacists and other health care professionals involved in CAR-T and other Immune Effector Cell (IECs) therapies."

The second edition was first presented at the 51st Annual Meeting of the EBMT in April 2025 in Florence, Italy, and subsequently at the EHA Annual Congress in June 2025. It is freely available online, underscoring the EBMT, EHA, and GoCART Coalition's commitment to accessible education and knowledge-sharing in cellular therapies.

Provided by European Society for Blood and Marrow Transplantation