This Science News Wire page contains a press release issued by an organization and is provided to you "as is" with little or no review from Science X staff.

The protein TXNL2 provides human breast cancer cells with protection

December 1st, 2010

Some individuals supplement their diet with antioxidants to try to ensure that they maintain their health and prevent disease. A key target of antioxidants is reactive oxygen species (ROS), which have been linked to tumor development and progression. A team of researchers — led by Xiaojiang Cui, at the John Wayne Cancer Institute, Santa Monica; Ning-Hui Cheng, Baylor College of Medicine, Houston; and Ning Zhang, at Tianjin Medical University, China — have now determined that the protein TXNL2 helps protect human breast cancer cells from high levels of ROS. Of interest, knocking down TXNL2 levels in human breast cancer cells inhibited their ability to form tumors upon transplantation into mice. Furthermore, enhanced TXNL2 expression in primary breast cancer samples correlated with cancer spread to the lung and brain and with decreased survival. The authors therefore suggest that TXNL2 could be a new therapeutic target for the treatment of breast cancer.

More information:
View this article at: www.jci.org/articles/view/4314 … b9f6d6b93a68a2798fdc

Provided by Journal of Clinical Investigation

Citation: The protein TXNL2 provides human breast cancer cells with protection (2010, December 1) retrieved 16 August 2026 from https://sciencex.com/wire-news/52673184/the-protein-txnl2-provides-human-breast-cancer-cells-with-protec.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.