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The nature of the T cell-hepatocyte interactions alter CD4+ T-cell trafficking and cytokine expression, and may have an impact on T-cell effector function and the outcome of anti-viral immune responses.
Innate and adaptive immune responses play a critical role in clearing acute HCV infection. Evidence from models suggest that CD4+ T cells play a critical role in controlling acute HCV infection, but the mechanism(s) behind their failure to control chronic HCV replication are still unknown.
1. Stamataki, Z.et al. Lymphocyte-hepatocyte interactions: hepatitis C virus changes the rules. Abstract presented at The International Liver CongressTM 2011. www1.easl.eu/easl2011/program/ … sters/Abstract14.htm
Provided by European Association for the Study of the Liver