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In vivo RNAi screening identifies new regulators of liver regeneration

April 1st, 2011

This study establishes a unique system to perform in vivo RNAi screens for genetically dissecting the cellular signalling networks that regulate hepatocyte proliferation during chronic liver damage.

Functional in vivo validation studies show that stable knockdown of the candidate gene by different shRNAs can significantly increase the repopulation efficiency of mouse hepatocytes and also increase the regenerative capacity of chronically damaged mouse livers.

Such detailed understanding of the signalling pathways involved in hepatocyte proliferation control holds the promise of new therapies to increase the hepatic regenerative potential for future new strategies in HCC treatment.

More information:
Wuestefeld, T. et al. in vivo RNAi screening identifies new regulators of liver regeneration. Abstract presented at The International Liver CongressTM 2011. www1.easl.eu/easl2011/program/Orals/261.htm

Provided by European Association for the Study of the Liver

Citation: In vivo RNAi screening identifies new regulators of liver regeneration (2011, April 1) retrieved 14 August 2026 from https://sciencex.com/wire-news/63087736/in-vivo-rnai-screening-identifies-new-regulators-of-liver-regene.html

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