Could an apple a day keep sepsis away?

Sepsis kills more people than breast, colorectal, pancreatic, and prostate cancers combined. Outside of coronary care units, it is the leading cause of mortality in intensive care units. Every year 18 million people worldwide develop this potentially fatal disease. Thanks to a generous grant of $138,238.65 from the Jesse and Julie Rasch Foundation, Lawson Health Research Institute's Dr. Michael Sharpe is exploring a new sepsis therapy using Vitamin C.

Patients with sepsis develop a full-body infection that "plugs" their capillaries, deprives their tissues of oxygen, and compromises circulation to their organs. Ultimately, this starves the organs of important nutrients, causing them to become dysfunctional and eventually fail. Research shows patients developing sepsis could be particularly prone to infection due to coinciding Vitamin C deficiencies. By replenishing these levels to normal, Dr. Sharpe believes organ dysfunction could be moderated and outcomes could be improved.

To determine whether or not patients with sepsis could benefit from Vitamin C therapy, Dr. Sharpe has planned a two-phase study. The first phase will determine the optimal Vitamin C dosing schedule to replenish the losses in serum and white blood cells. The second phase will consist of a pilot study testing the therapy in a small group of septic patients. Based on the results, Dr. Sharpe hopes to justify a larger, multi-centered clinical trial in collaboration with the Canadian Critical Care Trials Group that will demonstrate a statistically relevant reduction in mortality.

"The origin of this project came from the important findings using animal models of sepsis by Drs. Chris Ellis and Karl Tyml at Lawson and The University of Western Ontario," Dr. Sharpe says. "They demonstrated the potential benefit of Vitamin C administration as a novel therapy for sepsis." Dr. Sharpe will continue to collaborate with Drs. Ellis and Tyml to further understand the mechanisms causing this benefit.

Dr. Sharpe is an Associate Scientist at Lawson, and a physician in the Program in Critical Care at London Health Sciences Centre's University Hospital. He is also a professor in the Department of Anesthesia and Perioperative Medicine, and the Department of Medicine, at the Schulich School of Medicine & Dentistry at Western.

Provided by Lawson Health Research Institute