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Medical Xpress / Pumitamig plus ifinatamab deruxtecan shows encouraging early activity in small cell lung cancer
The investigational combination of pumitamig and elfetabart drozuntecan (elfe-D) demonstrated a manageable safety profile and encouraging early antitumor activity in patients with small cell lung cancer (SCLC), according ...
Medical Xpress / Investigational EGFR x HER3 therapy supports Phase III dose after lung cancer trial
An investigational EGFR x HER3 antibody-drug conjugate demonstrated promising efficacy with a tolerable safety profile in patients with previously treated EGFR-mutated non-small cell lung cancer (NSCLC), supporting selection ...
Medical Xpress / Extended-interval tarlatamab dosing shows consistent activity and safety in previously treated small cell lung cancer
Extended-interval dosing regimens of tarlatamab demonstrated efficacy, safety and pharmacokinetic profiles generally consistent with the established every-two-week regimen in patients with previously treated small cell lung ...
Medical Xpress / Perioperative atezolizumab + chemotherapy more than doubles event-free survival in resectable stage II–IIIB NSCLC
Patients with resectable stage II–IIIB non-small cell lung cancer (NSCLC) treated with perioperative atezolizumab plus platinum-based chemotherapy experienced a median event-free survival of 62.8 months compared with 34.9 ...
Medical Xpress / Local consolidative therapy does not improve survival after dual immunotherapy in metastatic NSCLC
Adding local consolidative therapy (LCT) after induction treatment with nivolumab plus ipilimumab did not improve overall survival or progression-free survival in patients with metastatic non-small cell lung cancer (NSCLC), ...
Phys.org / Scientists discover a strange new form of ice that could help explain the interiors of Neptune and Uranus
Scientists have discovered that there is ice deep inside planets like Neptune and Uranus and want to find out what form it takes and how it behaves. They cannot dig for it and transport it all the way back to Earth, so they ...
Medical Xpress / Subcutaneous tarlatamab shows favorable safety profile and antitumor activity in extensive-stage small cell lung cancer
Subcutaneous administration of tarlatamab was well tolerated and demonstrated preliminary antitumor activity in patients with previously treated extensive-stage small cell lung cancer (ES-SCLC), according to findings from ...
Phys.org / How one RNA nucleotide switch activates fluorescent dyes
RhoBAST is a tiny RNA molecule that activates fluorescent dyes, enabling researchers to track RNA molecules in living cells with super-resolution. An international collaboration, which includes Ronald Micura and his team ...
Phys.org / New analysis reconstructs the dawn of dinosaurs and other reptiles
About 252 million years ago, at the end of the Permian Period, a large proportion of species on Earth rapidly became extinct. After this mass extinction, many groups of organisms began to recover, while reptiles known as ...
Phys.org / Brain's ability to hear a musical beat remains distinctly human, study suggests
The seemingly trivial ability to hear a regular pulse in music is a remarkable—and perhaps distinctively human—feature of the brain. In a wide-ranging critical review, Gábor Háden of the HUN-REN Research Centre for Natural ...
Phys.org / Blue light breaks long-standing chemistry rule, unlocking 3D drug building blocks
For more than a century, pharmaceutical companies have relied on flat structures called aromatic rings, which can help drugs bind to target sites in the body. They include benzene rings and other flat, nitrogen-containing ...
Phys.org / Giant volcanic blanket reveals hidden 'Pompeii' of Andean landscapes
A vast sheet of volcanic rock in the Andes has preserved clues to a buried landscape that existed 22 million years ago, according to a new study led by UCL (University College London) researchers.
