Medical Xpress news

Medical Xpress / Newly discovered mechanism of mitochondrial dysfunction in obesity may drive insulin resistance and type 2 diabetes

A newly discovered mechanism that leads to liver dysfunction may be a key factor in type 2 diabetes and other metabolic disorders in individuals with obesity, according to a new study led by Harvard T.H. Chan School of Public ...

May 30, 2025 in Diabetes
Medical Xpress / Small molecule inhibitors restore normal BRAF structure, offering insight into cancer-causing mutations

Researchers led by Université de Montréal pathology and cell-biology professor Marc Therrien have identified major structural changes that enable the BRAF protein to escape control and mimic its activation, giving it strong ...

May 30, 2025 in Oncology & Cancer
Medical Xpress / Fixing the leak: Blocking an opioid receptor for safer treatment of dopamine-related disorders

Dopamine, a small molecule derived from the amino acid tyrosine, plays a significant role in regulating multiple essential brain functions, including movement, mood and motivation as well as multiple cognitive functions, ...

May 30, 2025 in Psychology & Psychiatry
Medical Xpress / Innovative immunotherapy shows promise against aggressive T cell cancers

A new type of immunotherapy that targets aggressive blood cancers shows promising results alongside manageable side effects, according to the results of an international Phase I/II clinical trial led by researchers at Washington ...

May 30, 2025 in Oncology & Cancer
Medical Xpress / Triple therapy regimen significantly improves survival in BRAF V600E-mutated metastatic colorectal cancer

First-line treatment with the triplet combination of encorafenib, cetuximab and mFOLFOX6 significantly improved survival compared to the standard of care in patients with BRAF V600E-mutated metastatic colorectal cancer, according ...

May 30, 2025 in Oncology & Cancer
Medical Xpress / Therapeutic target could prevent chronic gut inflammation from turning into cancer

Chronic inflammatory bowel disease is challenging to treat and carries a risk of complications, including the development of bowel cancer. Young people are particularly affected: when genetic predisposition and certain factors ...

May 30, 2025 in Oncology & Cancer
Medical Xpress / Diagnostic tool creates stronger, longer-lasting bioluminescence signals to detect viruses

Mass General Brigham researchers are shining a powerful new light into the viral darkness with the development of Luminescence CAscade-based Sensor (LUCAS), a rapid, portable, highly-sensitive diagnostic tool for processing ...

Medical Xpress / Scientists create framework for analyzing metabolic data to predict disease risk

Statisticians from the National University of Singapore (NUS) have developed a pioneering approach for analyzing population-scale metabolomic data, marking a major advancement in the precision and depth of metabolic profiling. ...

May 30, 2025 in Health informatics
Medical Xpress / Study shows ripple effects from World War II detainment camps on Japanese Americans' reproductive health

West Virginia University research has revealed negative intergenerational reproductive health effects from the Japanese American detainment camps of World War II.

May 30, 2025 in Health
Medical Xpress / At-home heart attacks and cardiac deaths on the rise since COVID-19 pandemic

Heart attacks are the leading cause of death globally, yet some statistics from many different countries suggest these events declined in frequency since the COVID-19 pandemic.

May 30, 2025 in Cardiology
Medical Xpress / Researchers say malnutrition in infants 'far bigger problem than previously recognized', amid ongoing cuts

Over 10 million infants under six months old may currently be underweight, according to a new analysis of data collected across low- and middle-income countries (LMICs).

May 30, 2025 in Health
Medical Xpress / Cross-cultural analysis challenges Western-dominated understanding of autism communication

Autism spectrum disorders are associated with difficulties in social communication, long attributed to individual socio‐cognitive deficits. As a consequence of this perspective, stigma and pressure to conform to neurotypical ...

May 30, 2025 in Autism spectrum disorders