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Scratching the surface of psoriasis

October 15th, 2012

Psoriasis is a chronic inflammatory skin disorder that affects approximately 2% of the world's population. A group of inflammatory molecules known as interleukins activate an immune response that causes itchy skin, but it is unclear how the skin cells and immune cells communicate. In a study published in the Journal of Clinical Investigation, researchers led by Manfred Kopf at the Swiss Federal Institute of Technology in Zürich, Switzerland found that mice lacking interleukin-36 (IL-36) were protected from immune-mediated skin inflammation. These results indicate that IL-36 might be a useful therapeutic target in the treatment of psoriasis.

More information:
Psoriasiform dermatitis is driven by interleukin-36-mediated dendritic cell-keratinocyte crosstalk, Journal of Clinical Investigation.

Provided by Journal of Clinical Investigation

Citation: Scratching the surface of psoriasis (2012, October 15) retrieved 9 January 2026 from https://sciencex.com/wire-news/111759069/scratching-the-surface-of-psoriasis.html

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