Baicalin inhibits neurotoxicity of colistin sulfate effectively

Baicalin, a type of flavonoid extracted from the dried root of Scutellaria baicalensis georgi, has been shown to effectively inhibit cell apoptosis. Colistin sulfate, a cyclic cationic polypeptide antibiotic, has been shown to have renal and neurological side effects.

Dr. Hong Jiang and colleagues from Northeast Agricultural University assumed that baicalin would suppress colistin sulfate-induced neuronal apoptosis. In a study by Jiang et al, PC12 cells were pretreated with baicalin (25, 50 and 100 μg/mL), and exposed to 125 μg/mL colistin sulfate. Cell morphology markedly changed, and cell viability increased. Moreover, caspase-3 activity, lactate dehydrogenase level and free radical content decreased. Experimental results indicated that baicalin inhibited colistin sulfate-induced PC12 cell apoptosis by suppressing free radical injury, and reducing caspase-3 activity and lactate dehydrogenase activity.

These findings are published in the Neural Regeneration Research (Vol. 8, No. 28, 2013).

More information:
Jiang H, Lv PF, Li JC, Wang HJ, Zhou TZ, Liu YZ, Lin W. Baicalin inhibits colistin sulfate-induced apoptosis of PC12 cells. Neural Regen Res. 2013;8(28):2597-2604.

Provided by Neural Regeneration Research