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Gabapentin inhibits central sensitization during migraine

January 6th, 2014
Gabapentin inhibits central sensitization during migraine
After gabapentin intervention, neuronal discharge in the spinal trigeminal nucleus of migraine model rats was significantly reduced, indicating an inhibitory effect of gabapentin on sensitization. The upper picture is the analog input of the neuronal discharge. The lower picture is the neuronal discharge after filtering. Credit: Neural Regeneration Research

Gabapentin is a gamma-aminobutyric acid derivative, and was approved for the treatment of neuropathic pain by the U.S. Food and Drug Administration in 2002. However, little evidence is available on the effects and me-chanisms of action of gabapentin during the migraine attack period.

A recent study by Yanbo Zhang and colleague from Xuanwu Hospital, Capital Medical University in China showed that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine. Gabapentin can decrease neuronal excitability in spinal trigeminal nuclei and inhibit the formation of central sensitization during migraine by reducing excitatory amino acid content in the cerebrospinal fluid and by inhibiting protein kinase C activation. These findings were published in the Neural Regeneration Research (Vol. 8, No. 32, 2013).

More information:
Zhang YB, Shao G, Zhang W, Li SJ, Niu JZ, Hu DM, Yang MF, Ji XM. Gabapentin inhibits central sensitization during migraine. Neural Regen Res. 2013;8(32):3003-3012.

Provided by Neural Regeneration Research

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