Does apolipoprotein E mimetic peptide reduce neuronal apoptosis induced by DBI?
However, its impact on neurological function following diffuse brain injury is still unclear. Prof. Jianmin Li and team from the Affiliated Hospital of Hebei United University in China conducted a relevant study. These researchers found that apolipoprotein E-derived therapeutic peptide (0.6mg/kg and 1.2mg/kg) improved synaptic stability and improved learning and memory performance after diffuse brain injury. Furthermore, apolipoprotein E mimetic peptide protected against brain injury by reducing oxidative stress, thereby suppressing the ERK1/2-Bax mitochondrial apoptotic pathway and decreasing neuronal death.
These results have been published in the Neural Regeneration Research (Vol. 9, No. 5, 2014).
Zhao YN, Li JM, Tang QQ, Gao JL, Chen CX, Jing LW, Zhang P, Li SX. Apolipoprotein E mimetic peptide protects against diffuse brain injury. Neural Regen Res. 2014;9(5):463-473.
Provided by Neural Regeneration Research