This Science News Wire page contains a press release issued by an organization and is provided to you "as is" with little or no review from Science X staff.

What aggravates hippocampal neuronal injury in acute cerebral ischemia?

July 9th, 2014

Activation of extracellular signal-regulated kinase 1/2 has been demonstrated in acute cerebral ischemia.

Yaning Zhao and her colleagues, Hebei United University, China induced transient whole-brain ischemia by four-vessel occlusion in normal and diabetic rats and intravenously injected diabetic rats with extracellular signal-regulated kinase 1/2 30 minutes before ischemia as a pretreatment. Results showed that during the pathological progression of cerebral ischemia/reperfusion in rats, activation of extracellular signal-regulated kinase 1/2 exhibits protective effect on neuronal injury. Reduced extracellular signal-regulated kinase 1/2 decreases Ku70 activity, increases Bax expression and thereby increases the number of lost hippocampal neurons in diabetic rats after cerebral ischemia/reperfusion.

These results were published in Neural Regeneration Research (Vol. 9, No. 7, 2014).

More information:
Zhao YN, Ji JM, Tang QQ, Zhang P, Jing LW, Chen CX, Li SX. Regulation of extracellular signal-regulated kinase 1/2 influences hippocampal neuronal survival in a rat model of diabetic cerebral ischemia. Neural Regen Res. 2014;9(7):749-756.

Provided by Neural Regeneration Research

Citation: What aggravates hippocampal neuronal injury in acute cerebral ischemia? (2014, July 9) retrieved 28 March 2026 from https://sciencex.com/wire-news/166356451/what-aggravates-hippocampal-neuronal-injury-in-acute-cerebral-is.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.