Intranasal nerve growth factor repairs injured spinal cord neurons
Results showed that at 3 weeks after intranasal administration of nerve growth factor, the contents of nerve growth factor and its receptor in the spinal cord were increased, and the deficits in locomotor behaviors were improved. These findings indicate that intranasal nerve growth factor can bypass blood-brain barrier and affect spinal cord neurons in spinal cord injury.
These results provide experimental evidence for intranasal nerve growth factor for repair of spinal cord injury. Related results were published in Neural Regeneration Research (Vol. 9, No. 10, 2014).
Aloe L, Bianchi P, De Bellis A, Soligo M, Rocco ML. Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury. Neural Regen Res. 2014;9(10):1025-1030.
Provided by Neural Regeneration Research