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Meta-analysis uncovers poor outcomes due to hyperthermia after post-cardiac arrest cooling

October 23rd, 2017
Meta-analysis uncovers poor outcomes due to hyperthermia after post-cardiac arrest cooling
Therapeutic Hypothermia and Temperature Management is the only peer-reviewed journal providing clinical advances, best practices, and protocols on this critical, life-saving technology, including its application in cardiac arrest, spinal cord and traumatic brain injury, stroke, and burns. Credit: Mary Ann Liebert, Inc., publishers

Rebound hyperthermia, or fever, is common after controlled body cooling to treat comatose survivors of cardiac arrest, but a new study presents evidence of significantly worse neurologic outcomes. The study, which showed severe rebound hyperthermia to be associated with both significantly worse neurologic outcomes and mortality, is published in Therapeutic Hypothermia and Temperature Management, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

In the article entitled "Clinical Effect of Rebound Hyperthermia After Cooling Postcardiac Arrest: A Meta-Analysis," (online.liebertpub.com/doi/full … .1089/ther.2017.0009) coauthors Parth Makker, MD, Yumiko Kanei, MD, and Deepkia Misra, MD, Icahn School of Medicine, Mount Sinai Beth Israel, New York, NY, reviewed the results of studies published in the medical literature. These studies have produced conflicting results. The researchers performed a meta-analysis of multiple studies to gain a better understanding of the clinical significance of fever after therapeutic hypothermia treatment, which effects approximately half of patients.

"This timely publication is important because it emphasizes the potentially detrimental effects of rebound hyperthermia on neurological outcomes in survivors of cardiac arrest. This information should be taken into account during the rewarming phase of the hypothermic treatment," says W. Dalton Dietrich, III, PhD, Editor-in-Chief of Therapeutic Hypothermia and Temperature Management, Scientific Director of The Miami Project to Cure Paralysis, and Kinetic Concepts Distinguished Chair in Neurosurgery, University of Miami Leonard M. Miller School of Medicine.

More information:
Parth Makker et al, Clinical Effect of Rebound Hyperthermia After Cooling Postcardiac Arrest: A Meta-Analysis, Therapeutic Hypothermia and Temperature Management (2017). DOI: 10.1089/ther.2017.0009

Provided by Mary Ann Liebert, Inc

Citation: Meta-analysis uncovers poor outcomes due to hyperthermia after post-cardiac arrest cooling (2017, October 23) retrieved 23 September 2025 from https://sciencex.com/wire-news/270222687/meta-analysis-uncovers-poor-outcomes-due-to-hyperthermia-after-p.html
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