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Developmental biology: Factors of cell division

October 11th, 2021

Cell division is a fundamental process by which one cell generates a multicellular organism. Through this process, genetic material is distributed between two daughter cells by a spindle apparatus. The poles of the spindle apparatus are composed of centrioles, which are surrounded by a proteinaceous matrix. The integrity of the spindle poles is crucial to properly form the spindle apparatus and to faithfully divide the cell. Defects in cell division that lead to incorrect segregation of chromosomes can have grave consequences, and are associated with diseases such as cancer.

The group of Tamara Mikeladze-Dvali at the LMU Biocenter has now shown how the proteinaceous matrix and the centrioles are linked together to facilitate spindle pole integrity in C. elegans. The results of the study suggest that the protein PCMD-1 is an essential functional bridge between the centrioles and the surrounding matrix.

More information:
Lisa Stenzel et al, PCMD-1 bridges the centrioles and the PCM scaffold in C. elegans, Development (2021). DOI: 10.1242/dev.198416

Provided by Ludwig Maximilian University of Munich

Citation: Developmental biology: Factors of cell division (2021, October 11) retrieved 13 September 2025 from https://sciencex.com/wire-news/395424173/developmental-biology-factors-of-cell-division.html

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