Targeting blood lipids in atherosclerotic cardiovascular disease management

Strong evidence supports the importance of lipid-lowering and exercise therapies in the long-term therapy of atherosclerotic cardiovascular disease (ASCVD). Establishing efficient comprehensive intervention programs that combine pharmacological and exercise prescription is crucial to investigate with the aid of digital technologies.

A convenience sample of 25 ASCVD patients (57.8 ± 9.5 years, 76% males) was gathered. All participants were prescribed with 12-week home exercise program supervised by an app and bimonthly 75mg alirocumab subcutaneous injections. Follow up visits were scheduled at the end of 4th and 12th week.

The study is published in the journal Cardiovascular Innovations and Applications.

Nineteen participants completed the program with a retention rate of 76%. Sixteen (84.2%) participants received all six doses of alirocumab. The total management time of the 12-week program added up to 65.47 minutes per patient. Satisfaction score was 4.2 ± 0.6 and the User Version of the Mobile Application Rating Scale (uMARS) overall objective quality score on the app was 3.4 ± 0.7.

At the four-week and 12-week follow-ups, LDL-C levels reduced compared to baseline (−1.5 ± 0.8 mmol/L, P < 0.001, −1.6 ± 0.8 mmol/L, P < 0.001, respectively), along with TC (−1.8 ± 1.2 mmol/L, P < 0.001, −1.6 ± 1.3 mmol/L, P < 0.001, respectively), but not TG, HDL-C, GAD-7 and PHQ-9.

The integrated pharmaceutical and digital ERx intervention program was feasible and well accepted in ASCVD patients.

More information:
Xu Yi et al, Feasibility of an Integrated Digital and Pharmacological Approach Targeting Blood Lipids in Atherosclerotic Cardiovascular Disease Management, Cardiovascular Innovations and Applications (2024). DOI: 10.15212/CVIA.2024.0002

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