Medical Xpress news
Medical Xpress / Off-label cancer drugs deliver durable benefit for some patients in large trial
The largest published prospective evaluation of off-label targeted cancer therapies has shown that more patients could benefit from existing drugs. After including over 1,600 patients in the Dutch multicenter DRUP trial, ...
Medical Xpress / Buprenorphine found to be a safe treatment for opioid addiction in pregnancy
Children born to mothers who used buprenorphine for opioid addiction during pregnancy do not have a greater risk of neurodevelopmental disorders, such as ADHD and autism, compared with children whose mothers took methadone, ...
Medical Xpress / Air pollution associated with increased migraine activity
Air pollution is associated with increased migraine activity, according to a study published in Neurology. Both short-term and cumulative exposure to air pollution as well as climate factors such as heat and humidity were ...
Medical Xpress / Ultra-processed food intake tied to sharply higher obesity risk in adolescents
Adolescents who consume more ultra-processed foods (UPFs) have significantly higher odds of being overweight or obese, according to a new systematic review and meta-analysis published in the open-access journal PLOS One by ...
Medical Xpress / RNA sequencing platform unlocks rare disease diagnoses missed by standard tests
Researchers from Children's Hospital of Philadelphia (CHOP) developed a new RNA sequencing strategy that can reveal how genetic variants disrupt gene function and improve the diagnosis of rare diseases.
Medical Xpress / Genome-wide analysis reveals host–virus genetic interactions in cancer risk
A study from Columbia University Mailman School of Public Health reports a major advance in understanding how interactions between human and viral genomes shape disease risk. The research found that variations in the Epstein–Barr ...
Medical Xpress / A major cancer protein hijacks RNA editing, exposing a new weakness in prostate tumors
Northwestern Medicine scientists have uncovered an unexpected role for a well-known cancer-related protein, revealing a new layer of genetic regulation that could reshape how certain cancers are treated. In a new study published ...
Medical Xpress / Mitochondria keep key immune cells battle-ready by sustaining electron flow, study reveals
Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) show that active mitochondria maintain dendritic cells, the immune system's sentinels, in a "ready-to-respond" state, linking cellular ...
Medical Xpress / Immune system uses a conveyor belt-like process to edit defective antibodies, new research finds
The immune system's B cells create antibodies that can mount a response against just about anything—either destroying a pathogen or instructing the rest of the immune system to go after the offender. But what happens when ...
Medical Xpress / Genetic atlas reveals how human liver cells divide their labor
If scientists could shrink themselves to microscopic size and take a journey through the human body—like the submarine crew in the 1966 science fiction classic "Fantastic Voyage"—one of their first stops would no doubt be ...
Medical Xpress / A molecular movie captures cancer's great escape from targeted therapy
Cancer drugs are designed to shut tumors down. But sometimes, in the very act of attacking a tumor, treatment can also help a small fraction of cancer cells become harder to kill. A new study from researchers at the Institute ...
Medical Xpress / Blood-based DNA signals may help track osteosarcoma in children
Detecting whether osteosarcoma, a rare but aggressive bone cancer that most often affects children and adolescents, has returned or spread remains a major challenge for patients and doctors. Blood-based biomarkers, which ...